Endodontics is a dynamic and evolving specialty that lies at the heart of dental science, making the selection of endodontics thesis topics a critical milestone for MDS candidates. Focused on the diagnosis and treatment of dental pulp and periapical tissues, endodontics offers a wide spectrum of research avenues, from evaluating the efficacy of novel irrigants and obturation techniques to exploring regenerative endodontic therapies and advanced imaging modalities. Choosing impactful endodontics thesis topics enables students to align their research with real-world clinical challenges and emerging innovations, thus enhancing both academic and clinical relevance. Whether it’s investigating microbial resistance in root canal infections or assessing biocompatibility of new pulp capping agents, thoughtfully selected endodontics thesis topics can contribute meaningfully to evidence-based practice and long-term patient care. Ultimately, endodontics thesis topics serve as the academic foundation for aspiring endodontists to push boundaries, refine techniques, and elevate the standards of modern dental therapy.